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The exact cause isnt always clear, but common contributors include: Trauma or injury to the penis (often unnoticed) Surgery, especially for prostate cancer Genetics, including a family history of Dupuytren's contracture Inflammation, ageing, or smoking (Restorative Health Clinic, 2025) Over time, scar tissue forms inside the penis (within the tunica albuginea), causing it to bend or curve during an erection

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The presence of miRNA-associated proteins in the mitochondria was only recently recognized (summarized in Table 4 )

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Inducible NOS (iNOS) is known as one of the main enzymes involved in the mitochondrial lipid peroxidation and in neuropathy